منابع مشابه
Membrane repair and immunological danger.
Antigens are able to elicit productive immune responses only when second signals are provided by adjuvant molecules. It is well established that exogenously acquired, pathogen-associated molecular patterns fulfil this adjuvant role when recognized by specific receptors on antigen-presenting cells. Recent evidence points to the existence of another class of adjuvant, which is apparently released...
متن کاملImmunological tolerance: Danger – pathogen on the premises!
The March 22 issue of Science carried three articles [1–3] that claim to challenge a key principle of immunology, called self–non-self discrimination, by examining neonatal tolerance. These papers demonstrate that newborn mice can make immune responses if the antigen is appropriately presented. Is this a refutation of self–non-self discrimination as the authors believe? And does it prove the ‘d...
متن کاملDysferlin and muscle membrane repair.
The ability to repair membrane damage is conserved across eukaryotic cells and is necessary for the cells to survive a variety of physiological and pathological membrane disruptions. Membrane repair is mediated by rapid Ca(2+)-triggered exocytosis of various intracellular vesicles, such as lysosomes and enlargeosomes, which lead to the formation of a membrane patch that reseals the membrane les...
متن کاملMembrane Repair: Mechanisms and Pathophysiology.
Eukaryotic cells have been confronted throughout their evolution with potentially lethal plasma membrane injuries, including those caused by osmotic stress, by infection from bacterial toxins and parasites, and by mechanical and ischemic stress. The wounded cell can survive if a rapid repair response is mounted that restores boundary integrity. Calcium has been identified as the key trigger to ...
متن کاملEffective membrane model of the immunological synapse.
The immunological synapse is a patterned collection of different types of receptors and ligands that forms in the intercellular junction between T cells and antigen presenting cells during recognition. The synapse is implicated in information transfer between cells, and is characterized by different spatial patterns of receptors at different stages in the life cycle of T cells. We obtain a mini...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2005
ISSN: 1469-221X,1469-3178
DOI: 10.1038/sj.embor.7400505